Research of Associated Resistance to Antimicrobial Agents of Extended Spectrum Beta-Lactamases Escherichia Coli and Klebsiella pneumoniae Strains Isolated in Senegal

Introduction: Some strains of Escherichia coli and Klebsiella pneumoniae produce Extended Spectrum Beta-Lactamases (ESBL) may be responsible for various infections such as urinary infections. These Sick people are treated in the very serious cases by association antibiotics to class betalactamins, aminosids quinolons. But proliferation multi-drug resistant involves decreasing therapeutic success. That’s why epidemiological study must done all laboratories bacteriology. Purpose: The aim was research resistance phenotypes our E. K. ESBL compared others families antibiotics. Material methods: Thirty two (32) betalactamases isolated from either hospitalized patients or sick who came consultation were studied. Susceptibility antimicrobial agents determined using an antibiotic disk (Bio-Rad) diffusion method on Mueller-Hinton agar (Bio-Rad). results interpreted according Standards French Antibiogram Committee (CA-SFM). Results: showed that most these resistant. They many beta-lactamines also at 70,34% aminosids, 96,72% quinolons, 58,3% cotrimoxazol, 26,1% chloramphénicol 21,4% colistin ; about pneumoniae, they 72,6% 88,95% 86,7% 44,4% 25% colistin. sensitive 100% l’imipenem.